Transplant Ethics
Dr. Reese uses normative and empirical ethics analyses to make transplantation more fair and more efficient. His work has often addressed barriers to equity in the care of patients with kidney disease, including serious problems with lack of transparency with the use of race-based measurement of kidney disease, often without the patient’s knowledge or assent. This work, with Dr. Eneanya and published in JAMA, contributed to a major overhaul in the approach to estimating glomerular filtration rate by the leading nephrology societies. In clinical practice, Dr. Reese has called out the mis-use of race in eligibility for kidney transplantation. Advocacy by his group and many others led to national policy that overhauled how transplant centers across the US measure kidney function when deciding who can join the waiting list.
Recently, as multiple experiments with xenotransplantation are conducted, Dr. Reese has proposed criteria for the ethical selection and consent of patients who could participate in trials of transplanting xeno-kidneys. With colleagues, he also charted a pathway for regulatory agencies, transplant centers and biotechnology companies to engineer equity into the process of bringing xenotransplant into clinical care.
He has incorporated this normative scientific work with policy development on multiple committees of the United Network for Organ Sharing, which regulates organ allocation and professional standards for transplantation in the US. Dr. Reese served as Chair of the Ethics Committee, where he collaborated with Dr. Bob Veatch, among many others.
Publications
Reconsidering the Consequences of Using Race to Estimate Kidney Function
Eneanya ND, Yang W, Reese PP. Reconsidering the Consequences of Using Race to Estimate Kidney Function. JAMA. 2019 Jul 9;322(2):113-114. doi: 10.1001/jama.2019.5774. PMID: 31169890.
Racial disparities in preemptive waitlisting and deceased donor kidney transplantation: Ethics and solutions
Reese PP, Mohan S, King KL, Williams WW, Potluri VS, Harhay MN, Eneanya ND. Racial disparities in preemptive waitlisting and deceased donor kidney transplantation: Ethics and solutions. Am J Transplant. 2021 Mar;21(3):958-967. doi: 10.1111/ajt.16392. Epub 2020 Dec 3. PMID: 33151614.
Unique problems for the design of the first trials of transplanting porcine kidneys into humans
Reese PP, Gelb BE, Parent B. Unique problems for the design of the first trials of transplanting porcine kidneys into humans. Kidney Int. 2023 Feb;103(2):239-242. doi: 10.1016/j.kint.2022.10.009. Epub 2022 Nov 1. PMID: 36332727.
Engineering Equity Into the Promise of Xenotransplantation
Reese PP, Powe NR, Lo B. Engineering Equity Into the Promise of Xenotransplantation. Am J Kidney Dis. 2024 May;83(5):677-683. doi: 10.1053/j.ajkd.2023.09.019. Epub 2023 Nov 20. PMID: 37992981.
Promoting Safety, Transparency, and Quality in Xenotransplantation
Reese PP, Parent B. Promoting Safety, Transparency, and Quality in Xenotransplantation. Ann Intern Med. 2022 Jul;175(7):1032-1034. doi: 10.7326/M22-0539. Epub 2022 May 17. PMID: 35576589.
Eneanya ND, Yang W, Reese PP. Reconsidering the Consequences of Using Race to Estimate Kidney Function. JAMA. 2019 Jul 9;322(2):113-114. doi: 10.1001/jama.2019.5774. PMID: 31169890.
Reese PP, Mohan S, King KL, Williams WW, Potluri VS, Harhay MN, Eneanya ND. Racial disparities in preemptive waitlisting and deceased donor kidney transplantation: Ethics and solutions. Am J Transplant. 2021 Mar;21(3):958-967. doi: 10.1111/ajt.16392. Epub 2020 Dec 3. PMID: 33151614.
Reese PP, Gelb BE, Parent B. Unique problems for the design of the first trials of transplanting porcine kidneys into humans. Kidney Int. 2023 Feb;103(2):239-242. doi: 10.1016/j.kint.2022.10.009. Epub 2022 Nov 1. PMID: 36332727.
Reese PP, Powe NR, Lo B. Engineering Equity Into the Promise of Xenotransplantation. Am J Kidney Dis. 2024 May;83(5):677-683. doi: 10.1053/j.ajkd.2023.09.019. Epub 2023 Nov 20. PMID: 37992981.
Reese PP, Parent B. Promoting Safety, Transparency, and Quality in Xenotransplantation. Ann Intern Med. 2022 Jul;175(7):1032-1034. doi: 10.7326/M22-0539. Epub 2022 May 17. PMID: 35576589.