Health Behavior Change

Dr. Reese is keenly interested in health behavior change, particularly in the domain of medication non-adherence. Medication non-adherence is severely detrimental to health outcomes in virtually every domain of clinical medicine and may be responsible for the immense problem of incomplete transformation of research findings from clinical trials into better patient outcomes. In collaboration with Dr. Volpp and others in Center for Health Incentives and Behavioral Economics (CHIBE), Dr. Reese has led or continues leading 9 randomized trials, including those focused on improving medication adherence (5), fluid intake to prevent kidney stones (1), and diet strategies (1) to reduce phosphorus in dialysis patients. These trials involved important levers of behavior change, including structured problem solving, financial incentives as well as the efficient and creative use of technology to alert physicians to non-adherent patients. He has also developed novel methodological approaches to adapt and intensify interventions based on real-time data from wireless devices about the success of the initial intervention on behavior change. Related manuscripts have been published in the Journal of General Internal Medicine as well as the American Journal of Kidney Diseases.

Automated Reminders and Physician Notification to Promote Immunosuppression Adherence Among Kidney Transplant Recipients: A Randomized Trial

Reese PP, Bloom RD, Trofe-Clark J, Mussell A, Leidy D, Levsky S, Zhu J, Yang L, Wang W, Troxel A, Feldman HI, Volpp K. Automated Reminders and Physician Notification to Promote Immunosuppression Adherence Among Kidney Transplant Recipients: A Randomized Trial. Am J Kidney Dis. 2017 Mar;69(3):400-409. doi: 10.1053/j.ajkd.2016.10.017. Epub 2016 Dec 7. PMID: 27940063.

Two Randomized Controlled Pilot Trials of Social Forces to Improve Statin Adherence among Patients with Diabetes

Reese PP, Kessler JB, Doshi JA, Friedman J, Mussell AS, Carney C, Zhu J, Wang W, Troxel A, Young P, Lawnicki V, Rajpathak S, Volpp K. Two Randomized Controlled Pilot Trials of Social Forces to Improve Statin Adherence among Patients with Diabetes. J Gen Intern Med. 2016 Apr;31(4):402-10. doi: 10.1007/s11606-015-3540-y. PMID: 26585957; PMCID: PMC4803690.

Effect of Financial Incentives for Process, Outcomes, or Both on Cholesterol Level Change: A Randomized Clinical Trial

Reese PP, Barankay I, Putt M, Russell LB, Yan J, Zhu J, Huang Q, Loewenstein G, Andersen R, Testa H, Mussell AS, Pagnotti D, Wesby LE, Hoffer K, Volpp KG. Effect of Financial Incentives for Process, Outcomes, or Both on Cholesterol Level Change: A Randomized Clinical Trial. JAMA Netw Open. 2021 Oct 1;4(10):e2121908. doi: 10.1001/jamanetworkopen.2021.21908. PMID: 34605920; PMCID: PMC8491106.

A randomized, controlled, prehabilitation intervention to maximize early recovery (PRIMER) in liver transplantation

Serper M, Jones LS, Clement T, Reddy RK, Reese PP. A randomized, controlled, prehabilitation intervention to maximize early recovery (PRIMER) in liver transplantation. Liver Transpl. 2024 Jan 1;30(1):10-19. doi: 10.1097/LVT.0000000000000198. Epub 2023 Jun 29. PMID: 37379030; PMCID: PMC10755068.